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In a systematic review and meta-analysis of four randomized controlled trials including over 3,700 subjects, combination therapy with an SGLT2 inhibitor and metformin beginning at diabetes diagnosis resulted in greater weight loss and reduction of HbA1C levels compared with either drug alone

GLP-1 drugs alone have a very powerful track record of safety, Drucker said, but every time we add something to it, were starting again. And even just targeting one hormone, GLP-1, has been transformative

They may use provocative behavior and seek to be the center of attention

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Two-year effects of GLP1 in adults with overweight or obesity: The STEP 5 trial